Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones.

@article{Pollicino2006HepatitisBV,
  title={Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones.},
  author={Teresa Pollicino and Laura Belloni and Giuseppina Raffa and Natalia Pediconi and Giovanni Squadrito and Giovanni Raimondo and Massimo Levrero},
  journal={Gastroenterology},
  year={2006},
  volume={130 3},
  pages={
          823-37
        }
}
BACKGROUND & AIMS HBV covalently closed circular DNA (cccDNA), the replicative intermediate responsible for persistent HBV infection of hepatocytes, is the template for transcription of all viral mRNAs. Nuclear cccDNA accumulates as a stable episome organized into minichromosomes by histone and nonhistone proteins. In this study we investigated, by a newly developed sensitive and specific assay, the relationship between viral replication and HBV chromatin assembly, transcription, and… CONTINUE READING
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