Hepatitis B virus replication induces methylation of both host and viral DNA.

@article{Vivekanandan2010HepatitisBV,
  title={Hepatitis B virus replication induces methylation of both host and viral DNA.},
  author={Perumal Vivekanandan and Hubert Darius-J Daniel and Rajesh Kannangai and Francisco Mart{\'i}nez-Murillo and Michael S. Torbenson},
  journal={Journal of virology},
  year={2010},
  volume={84 9},
  pages={4321-9}
}
Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from chronic hepatitis B virus (HBV) infection. Recently, methylation has been identified as a novel host defense mechanism, and methylation of viral DNA leads to downregulation of HBV gene expression. To better understand the mechanisms of HBV methylation, cell lines were exposed to HBV using a model system that mimics natural infection and the expression of host DNA methyltransferase genes (DNMTs) was… CONTINUE READING
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