Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells.

@article{Zhang2011HepatitisBV,
  title={Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells.},
  author={Lei Zhang and Xuefei Cai and Ke Chen and Zengchan Wang and Liying Wang and Min Ren and Ailong Huang and Hua Tang},
  journal={Virus research},
  year={2011},
  volume={157 1},
  pages={76-81}
}
The hepatitis B virus (HBV) protein plays a major role in hepatocellular carcinoma (HCC) development. However, its contribution to tumor invasion and metastasis has not been established so far. HLJ1 was recently cloned and classified as a member of the heat shock protein 40 family (Hsp40/DnaJ) which is abundantly expressed in HBV-related tumors, might be involved in tumor progression. In this study, the role of HBV in activation of HLJ1 was investigated. In HepG2 cells with transit or stable… CONTINUE READING

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