Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice.

@article{Zheng2007HepatitisBV,
  title={Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice.},
  author={Yanyan Zheng and Wen-ling Chen and Stan Gee Louie and T. S. Benedict Yen and Jing-Hsiung James Ou},
  journal={Hepatology},
  year={2007},
  volume={45 1},
  pages={
          16-21
        }
}
UNLABELLED HBV is a major risk factor for hepatocellular carcinoma (HCC). However, whether HBV can directly cause HCC or only indirectly via the induction of chronic liver inflammation has been controversial. By using transgenic mice carrying the entire HBV genome as a model, we now demonstrate that HBV by itself is an inefficient carcinogen. However, it can efficiently promote hepatocarcinogenesis initiated by the carcinogen diethylnitrosamine (DEN). This effect of HBV does not involve chronic… CONTINUE READING
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