Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.

@article{Liu2015HepatitisBV,
  title={Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.},
  author={Yinghui Liu and Jianhua Li and Jieliang Chen and Yaming Li and Weixia Wang and Xiaoting Du and Wuhui Song and Wen Zhang and Li Lin and Zhenghong Yuan},
  journal={Journal of virology},
  year={2015},
  volume={89 4},
  pages={
          2287-300
        }
}
UNLABELLED The cellular innate immune system recognizing pathogen infection is essential for host defense against viruses. In parallel, viruses have developed a variety of strategies to evade the innate immunity. The hepatitis B virus (HBV), a DNA virus that causes chronic hepatitis, has been shown to inhibit RNA helicase RIG-I-mediated interferon (IFN) induction. However, it is still unknown whether HBV could affect the host DNA-sensing pathways. Here we report that in transiently HBV… CONTINUE READING

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