Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocopetentent rats.

AIM To characterize the host response to hepatitis B virus (HBV) infection in human hepatocytes transplanted into immunocompetent rodent rats tolerized by, and transplanted with primary human hepatocytes. METHODS One week after the transplantation, rats were inoculated with HBV, and viral gene expression, replication, and host response was monitored… CONTINUE READING