Hepatitis B virus infection and primary hepatocellular carcinoma

@article{Feitelson1992HepatitisBV,
  title={Hepatitis B virus infection and primary hepatocellular carcinoma},
  author={Mark Alan Feitelson},
  journal={Clinical Microbiology Reviews},
  year={1992},
  volume={5},
  pages={275 - 301}
}
  • M. Feitelson
  • Published 1 July 1992
  • Medicine, Biology
  • Clinical Microbiology Reviews
For many years, epidemiological studies have demonstrated a strong link between chronic hepatitis B virus (HBV) infection and the development of primary hepatocellular carcinoma (PHC). Other hepatocarcinogens such as hepatitis C virus and aflatoxin also contribute to hepatocarcinogenesis either in conjunction with HBV infection or alone. Cellular and molecular biological studies are providing explanations for the HBV-PHC relationship, and models are now being formulated to further test the… 
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TLDR
Investigation of immunotherapy for chronic HBV infection in a chimpanzee HBV carrier using recombinant DNA‐based immunization followed by a recombinant canarypox booster found decline in HBV DNA correlated with a boost in gamma interferon production without a corresponding boost in cytotoxic T lymphocyte levels.
Integrity of p 53 in Hepatitis B x Antigen-positive and-negative Hepatocellular
TLDR
HBxAg is a common marker of HCC that correlates with the persistence of wild-type p53 among both carriers and noncarriers and the low frequency of p53 mutatIons in HCC in these patients is tested, suggesting that p53 InactIvation may occur predominantly by corn plex formation with HBxAg.
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