Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants.

  title={Hepatitis B virus-induced hepatocellular carcinoma: functional roles of MICA variants.},
  author={Hoang van Tong and Nguyen Linh Toan and Le Huu Song and C T Bock and Peter Gottfried Kremsner and Thirumalaisamy P Velavan},
  journal={Journal of viral hepatitis},
  volume={20 10},
Hepatitis B virus infection is a high-risk factor for hepatocellular carcinoma. The human major histocompatibility complex class I chain-related gene A (MICA) is a ligand of the NKG2D receptor that modulates the NK and T-cell-mediated immune responses and is associated with several diseases. This study determined the effects of MICA polymorphisms during HBV infection and HBV-induced HCC. We conducted a case-controlled study in a Vietnamese cohort and genotyped ten functional MICA polymorphisms… CONTINUE READING
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