Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape.

@article{Beckebaum2003HepatitisBV,
  title={Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape.},
  author={Susanne Beckebaum and Vito Rosario Cicinnati and Xia Zhang and Stanislav Feren{\vc}{\'i}k and Andrea Frilling and Hans Grosse-Wilde and Christoph Erich Broelsch and Guido G H Gerken},
  journal={Immunology},
  year={2003},
  volume={109 4},
  pages={487-95}
}
Dendritic cells (DC) are the most potent antigen-presenting cells and play a central role in the induction of antiviral immune responses. Recently, we have shown that monocyte-derived DC (MoDC) from patients with chronic hepatitis B virus (HBV) infection are functionally impaired. In our present study MoDC from healthy subjects were propagated in vitro and inoculated with HBV particles to investigate the precise mechanisms that underly MoDC dysfunction. T-cell proliferation assays revealed an… CONTINUE READING

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