Hepatitis B virus genotypes among chronic hepatitis B patients from Baghdad, Iraq and their impact on liver function

  title={Hepatitis B virus genotypes among chronic hepatitis B patients from Baghdad, Iraq and their impact on liver function},
  author={Rana Talb Mohsen and Raghad H. Al-azzawi and Ali Hussein Ad’hiah},
  journal={Gene Reports},
2 Citations
Serum Level of Interleukin-35 in Patients with Chronic Hepatitis B Virus Infection
Results confirmed the role of IL-35 in the pathogenesis of hepatitis B virus (HBV) infection in Iraqi patients with chronic HBV.
Hepatocellular Cancer in Iran


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It is concluded that HBV D genotype was the predominant, in addition, A, B, C, and F genotypes are reported for the first time in Iraq and may be Arab countries and Mediterranean Region.
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Investigation of the distribution of genotypes and its association with severity of liver disease in patients with Chronic Hepatitis B (CHB) in Uttar Pradesh, India showed that Genotype D was the commonest genotype in UP, whereas genotype A had significantly more elevated ALT/AST levels than genotype D.
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Genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment, as pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC.
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Characterizing the HBV burden, circulating sub-genotypes, and clinically relevant mutations among blood donors in Botswana is important to elucidate the efficacy of currently available vaccines, predicting HBV-transmission patterns, understanding the cohort’s risk toHBV-related complications, and to developing prevention strategies and effective genotype-based antiretroviral therapies.
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It is estimated that 96% of chronic HBV infections worldwide are caused by five of the nine genotypes, and the need to provide HBV cell culture and animal models that cover at least genotypes A to E and represent the vast majority of globalHBV infections to test novel treatment strategies is highlighted.
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