Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection.

@article{Meier2017HepatitisBV,
  title={Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection.},
  author={M-A Meier and Aleksei Suslov and Sylvia Ketterer and Markus H Heim and S F Wieland},
  journal={Journal of viral hepatitis},
  year={2017},
  volume={24 8},
  pages={
          662-671
        }
}
Current treatment options for patients with chronic hepatitis B virus (HBV) infection are not curative as they are not effective in eliminating covalently closed circular DNA (cccDNA). cccDNA is a stable template for HBV transcription in the nucleus of hepatocytes and is thought to be one of the main factors responsible for HBV persistence. Recently, activation of the lymphotoxin beta receptor (LTβR) has been shown to trigger degradation of cccDNA through induction of cytidine deaminases of the… CONTINUE READING

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