Hepatitis B virus X protein suppresses all-trans retinoic acid-induced apoptosis in human hepatocytes by repressing p14 expression via DNA methylation.

@article{Choi2017HepatitisBV,
  title={Hepatitis B virus X protein suppresses all-trans retinoic acid-induced apoptosis in human hepatocytes by repressing p14 expression via DNA methylation.},
  author={Jung-Hye Choi and Hyerin Jeong and Kyung Lib Jang},
  journal={The Journal of general virology},
  year={2017},
  volume={98 11},
  pages={2786-2798}
}
All-trans retinoic acid (ATRA), the most biologically active metabolite of vitamin A, is known to activate p14 expression via promoter hypermethylation to induce p53-dependent apoptosis in human hepatocytes. In this study, we found that the oncogenic hepatitis B virus (HBV) X protein (HBx) of HBV, derived from both overexpression and 1.2-mer replicon… CONTINUE READING