Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death.

@article{Leupin2005HepatitisBV,
  title={Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death.},
  author={Olivier Leupin and S{\'e}verine Bontron and C{\'e}line Schaeffer and Michel Strubin},
  journal={Journal of virology},
  year={2005},
  volume={79 7},
  pages={4238-45}
}
The hepatitis B virus (HBV) X protein (HBx) is essential for virus infection and has been implicated in the development of liver cancer associated with chronic infection. HBx can interact with a number of cellular proteins, and in cell culture, it exhibits pleiotropic activities, among which is its ability to interfere with cell viability and stimulate HBV replication. Previous work has demonstrated that HBx affects cell viability by a mechanism that requires its binding to DDB1, a highly… CONTINUE READING
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