Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.

  title={Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.},
  author={Xiaojie Xu and Zhongyi Fan and Lei Kang and Juqiang Han and Chengying Jiang and Xiaofei Zheng and Ziman Zhu and Huabo Jiao and Jing Lin and Kai Jiang and Lihua Ding and Hao Zhang and Long Cheng and Hanjiang Fu and Yi Song and Y Jiang and Jiahong Liu and Rongfu Wang and Nan Du and Qinong Ye},
  journal={The Journal of clinical investigation},
  volume={123 2},
MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood. Here, we report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote cancer growth and metastasis in a mouse model of hepatocellular carcinoma (HCC). Hematopoietic pre-B cell leukemia transcription factor-interacting protein (HPIP) is an important regulator of cancer cell growth. We… CONTINUE READING


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