Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway

@inproceedings{Wang2012HepatitisBV,
  title={Hepatitis B virus X protein promotes the growth of hepatocellular carcinoma by modulation of the Notch signaling pathway},
  author={Fan Wang and Haiyan Zhou and Yuzhen Yang and Xiumei Xia and Qian Sun and Jin Luo and Bin Cheng},
  booktitle={Oncology reports},
  year={2012}
}
Hepatitis B virus X protein (HBx) plays a crucial role in the development of hepatocellular carcinoma (HCC), however, little is known about the mechanism. Here, we investigated the relationship between HBx and Notch signaling in HepG2 cells after they were transfected with the HBx gene. It was found that HBx upregulated the expression of Notch-1, Jagged-1 and Hes-1 at the transcriptional level by binding to the Notch-1 intracellular… CONTINUE READING

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