Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells.

@article{Cha2004HepatitisBV,
  title={Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells.},
  author={M S Cha and Chang-Myeong Kim and Young-min Park and Wang-Shick Ryu},
  journal={Hepatology},
  year={2004},
  volume={39 6},
  pages={1683-93}
}
Wnt/beta-catenin signaling contributes to diverse cellular functions, such as Drosophila wing development and colon carcinogenesis. Recently, stabilizing mutations of beta-catenin, a hallmark of Wnt signaling, were documented in significant numbers of primary hepatocellular carcinomas (HCC). However, whether the beta-catenin mutation leads to the activation of Wnt/beta-catenin signaling in hepatoma cells has not been established. We found that Wnt/beta-catenin signaling could be activated by… CONTINUE READING

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