Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

@article{Wang1994HepatitisBV,
  title={Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.},
  author={Xin Wei Wang and Kathleen S Forrester and Huery Ren Yeh and Mark Alan Feitelson and Jian Ren Gu and Curtis C. Harris},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 6},
  pages={2230-4}
}
Chronic active hepatitis caused by infection with hepatitis B virus, a DNA virus, is a major risk factor for human hepatocellular carcinoma. Since the oncogenicity of several DNA viruses is dependent on the interaction of their viral oncoproteins with cellular tumor-suppressor gene products, we investigated the interaction between hepatitis B virus X protein (HBX) and human wild-type p53 protein. HBX complexes with the wild-type p53 protein and inhibits its sequence-specific DNA binding in… CONTINUE READING
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