Hepatitis B virus X protein inhibits nucleotide excision repair.

  title={Hepatitis B virus X protein inhibits nucleotide excision repair.},
  author={Libin Jia and Xin Wei Wang and Curtis C. Harris},
  journal={International journal of cancer},
  volume={80 6},
Human hepatitis B virus (HBV) is a major risk factor of human hepatocellular carcinoma. Both in vivo and in vitro studies have shown that HBV X protein (HBx) can bind to the p53 tumor-suppressor protein and interfere with the role that p53 plays in the cellular response to DNA damage. Our previous work has shown that HBx protein inhibits p53 sequence-specific transcriptional activation, p53-mediated apoptosis and p53 binding to the TFIIH transcription-nucleotide excision repair (NER) factors… CONTINUE READING


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