Hepatitis B virus X protein (HBx)-induced abnormalities of nucleic acid metabolism revealed by 1H-NMR-based metabonomics

@article{Yue2016HepatitisBV,
  title={Hepatitis B virus X protein (HBx)-induced abnormalities of nucleic acid metabolism revealed by 1H-NMR-based metabonomics},
  author={Dan Yue and Yuwei Zhang and L. Cheng and Jinhu Ma and Yufeng Xi and Liping Yang and C. Su and Bin Shao and Anliang Huang and R. Xiang and P. Cheng},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Hepatitis B virus X protein (HBx) plays an important role in HBV-related hepatocarcinogenesis; however, mechanisms underlying HBx-mediated carcinogenesis remain unclear. In this study, an NMR-based metabolomics approach was applied to systematically investigate the effects of HBx on cell metabolism. EdU incorporation assay was conducted to examine the effects of HBx on DNA synthesis, an important feature of nucleic acid metabolism. The results revealed that HBx disrupted metabolism of glucose… Expand
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