Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response.

@article{Li2007HepatitisBV,
  title={Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response.},
  author={Baozong Li and Bo Gao and Linbai Ye and Xue Han and Wei Wang and Lingbao Kong and Xiaonan Fang and Yingchun Zeng and Hong Yuan Zheng and Shanshan Li and Zhenghui Wu and Li Yun Ye},
  journal={Virus research},
  year={2007},
  volume={124 1-2},
  pages={
          44-9
        }
}
Numerous viruses including hepatitis B virus (HBV) induce endoplasmic reticulum (ER) stress, which interrupts protein folding causing accumulation of unfolded or misfolded proteins in ER. To alleviate the stress placed on ER, these proteins must be refolded or degraded by activating a specific cellular response known as ER stress response or unfolded protein response (UPR). Two UPR-specific signaling pathways involving transmembrane proteins ATF6 and XBP1 generate critical transcription factors… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

Similar Papers

Loading similar papers…