Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment

  title={Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment},
  author={A P Huovila and Astrid M Eder and Stephen D. Fuller},
  journal={The Journal of Cell Biology},
  pages={1305 - 1320}
Expression of hepatitis B surface antigen (HBsAg), the major envelope protein of the virus, in the absence of other viral proteins leads to its secretion as oligomers in the form of disk-like or tubular lipoprotein particles. The observation that these lipoprotein particles are heavily disulphide crosslinked is paradoxical since HBsAg assembly is classically believed to occur in the ER, and hence in the presence of high levels of protein disulphide isomerase (PDI) which should resolve these… CONTINUE READING
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