Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.

@article{Eble1986HepatitisBS,
  title={Hepatitis B surface antigen: an unusual secreted protein initially synthesized as a transmembrane polypeptide.},
  author={B E Eble and Vishwanath R. Lingappa and Donald E Ganem},
  journal={Molecular and cellular biology},
  year={1986},
  volume={6 5},
  pages={
          1454-63
        }
}
Hepatitis B surface antigen (HBsAg), the major coat protein of hepatitis B virus, is also secreted from cells as a subviral particle, without concomitant cleavage of N-terminal amino acid sequences. We examined this unusual export process in a cell-free system and showed that the initial product of HBsAg biosynthesis is an integral transmembrane protein, with most or all of its C-terminal half on the lumenal side of the endoplasmic reticulum membrane. To study the nature of its topogenic… CONTINUE READING

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