Hepatitis B immunoglobulin prophylaxis after liver transplantation: experience in a tertiary transplant centre.


BACKGROUND Prophylaxis with hepatitis B immunoglobulin (HBIG) and nucleoside analogs can prevent hepatitis B virus (HBV) recurrence after liver transplant (LT). AIM To determine the efficacy and cost of maintaining immunoprophylaxis with HBIG and hyperimmune plasma (HIP) for 6 months after LT. MATERIAL & METHODS The study included 22 HBV related LT recipients who were on entecavir and either HBIG or HIP for 6 months. Post transplant HBIG or HIP dose and cost incurred towards prophylaxis were noted. The cost of 200 IU of HBIG at the time of study was Rs 8250/- (US Dollars 135) and that of 2000 IU of HIP was Rs 8000/- (USD 130.7). The loading and maintenance costs at end of 6 months were compared between the two groups. Response to HBIG and HIP was assessed by checking for HBsAg reactivity, anti HBs titer response and HBV DNA viral load. STATISTICAL ANALYSIS Median and range, Kruskal Wallis (KW) sign rank Sum Test and Correlation Coefficient (r2) was used for analysis. RESULTS Thirteen recipients received HBIG and 9 recipients HIP. The anti HBs response to HIP was significantly high compared to HBIG (KW Sign rank Sum test P < 0.05); titers remained high until the study period. Between 8 and 30 days, the titer achieved by both HBIG and HIP was similar (KW Sign rank Sum test not significant). Despite low anti HBs titer of <100 IU/L, none of the recipients on HBIG had HBsAg reactivity while 3 on HIP had transient HBsAg positivity. The total cost with HBIG was 13.9 times the cost of HIP. CONCLUSION HIP immunoprophylaxis in combination with entecavir achieves a high anti HBs titer at a significant low cost during anhepatic and loading phase. HBV reactivation rates with HBIG and HIP is low despite low anti HBs titer.

DOI: 10.1016/j.jceh.2014.07.007

Cite this paper

@article{Varghese2014HepatitisBI, title={Hepatitis B immunoglobulin prophylaxis after liver transplantation: experience in a tertiary transplant centre.}, author={Joy S Varghese and Deepti Sachan and Mettu Srinivas Reddy and Tom Cherian and Dinesh Jothimani and Kota Venugopal and Olithselvan Arikichenin and Rajasekar Perumalla and Gomathy Narasimhan and Vivekananthan Shanmugam and Srinivasan Vijaya and Jayanthi Venkataraman and Mohamed Rela}, journal={Journal of clinical and experimental hepatology}, year={2014}, volume={4 3}, pages={209-13} }