Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre study.

@article{Zanetti2010HepatitisBI,
  title={Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre study.},
  author={A. Zanetti and L. Romanò and C. Giambi and A. Pavan and V. Carnelli and G. Baitelli and G. Malchiodi and E. Valerio and A. Barale and M. Marchisio and D. Mont{\`u} and A. Tozzi and F. D'Ancona},
  journal={The Lancet. Infectious diseases},
  year={2010},
  volume={10 11},
  pages={
          755-61
        }
}
BACKGROUND In 2000, hexavac and infanrix hexa were licensed in Europe for primary immunisation of children against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and invasive infections caused by Haemophilus influenzae b. In 2005, hexavac was suspended because of concerns about the long-term immunogenicity of its hepatitis B component. We aimed to assess the duration of immunity and need for booster injections in children primed with these vaccines. METHODS In an open-label… Expand
Booster hepatitis B vaccination not necessary for long-term protection in children immunised with hexavalent vaccines.
Loss of antibodies, but not of protection.
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