Hepatitis B immune globulin for life versus limited use: I favor limited duration of therapy

@article{Lake2002HepatitisBI,
  title={Hepatitis B immune globulin for life versus limited use: I favor limited duration of therapy},
  author={John R. Lake},
  journal={Liver Transplantation},
  year={2002},
  volume={8}
}
  • J. Lake
  • Published 1 October 2002
  • Medicine
  • Liver Transplantation
The initial enthusiasm for performing orthotopic liver transplantation (OLT) on patients with chronic hepatitis B virus (HBV) infectionwas tempered in the early 1990s by a high rate of recurrent infection, with the subsequent development of severe recurrent hepatitis frequently leading to loss of the allograft.1 In the absence of effective therapy, recurrent infection, defined as the appearance after OLT of detectable hepatitis B surface antigen (HBsAg) in serum, occurred in 70% to 90%2 of… 
1 Citations
Management of chronic hepatitis B in the liver transplant setting
TLDR
Five-year resistance surveillance programs are currently ongoing to monitor the emergence of ADV-resistant mutants in the long-term, and newer nucleoside analogs may provide a rescue therapy for LAM-resistant strains to avoid potential aggressive courses of HBV graft reinfection in liver transplant recipients.

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TLDR
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