Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.

@article{Ni2014HepatitisBA,
  title={Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.},
  author={Yi Ni and Florian A. Lempp and Stefan Mehrle and Shirin Nkongolo and Christina Kaufman and Maria F{\"a}lth and Jan Stindt and Christian K{\"o}niger and Michael Nassal and Ralf Kubitz and Holger S{\"u}ltmann and Stephan Urban},
  journal={Gastroenterology},
  year={2014},
  volume={146 4},
  pages={1070-83}
}
BACKGROUND & AIMS Hepatitis B and D viruses (HBV and HDV) are human pathogens with restricted host ranges and high selectivity for hepatocytes; the HBV L-envelope protein interacts specifically with a receptor on these cells. We aimed to identify this receptor and analyze whether it is the recently described sodium-taurocholate co-transporter polypeptide (NTCP), encoded by the SLC10A1 gene. METHODS To identify receptor candidates, we compared gene expression patterns between differentiated… CONTINUE READING
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