Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ

@inproceedings{Kim2007HepatitisBV,
  title={Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ},
  author={Kook Hwan Kim and Hye–Jun Shin and Kyeongjin Kim and Hyun Shin Choi and Sang Hoon Rhee and Hyung Bae Moon and Hyeong Hoe Kim and Ung Suk Yang and Dae Yeul Yu and Jaehun Cheong},
  year={2007}
}
Background & Aims: Hepatic steatosis occurs frequently in patients with chronic hepatitis B virus (HBV) or chronic hepatitis C virus (HCV) infection. Recently, several studies suggested that steatosis plays an important role as a cofactor in other liver diseases such as hepatic fibrosis, hepatitis, and liver cancer. In contrast to HCV, however, the molecular mechanism by which HBV mediates hepatic steatosis has not been clearly studied. Here, we show the molecular mechanism by which hepatitis B… CONTINUE READING

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