Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ

@article{Kim2007HepatitisBV,
  title={Hepatitis B Virus X Protein Induces Hepatic Steatosis Via Transcriptional Activation of SREBP1 and PPARγ},
  author={K. H. Kim and Hye–Jun Shin and Kyeongjin Kim and H. T. Choi and S. Rhee and H. B. Moon and H. Kim and U. Yang and D. Y. Yu and J. Cheong},
  journal={Gastroenterology},
  year={2007},
  volume={132},
  pages={1955-1967}
}
  • K. H. Kim, Hye–Jun Shin, +7 authors J. Cheong
  • Published 2007
  • Biology
  • Gastroenterology
  • Background & Aims: Hepatic steatosis occurs frequently in patients with chronic hepatitis B virus (HBV) or chronic hepatitis C virus (HCV) infection. Recently, several studies suggested that steatosis plays an important role as a cofactor in other liver diseases such as hepatic fibrosis, hepatitis, and liver cancer. In contrast to HCV, however, the molecular mechanism by which HBV mediates hepatic steatosis has not been clearly studied. Here, we show the molecular mechanism by which hepatitis B… CONTINUE READING
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