Hepatitis B Surface Antigen as Carrier Matrix for the Repetitive Epitope of the Circumsporozoite Protein of Plasmodium Falciparum.

@article{Rutgers1988HepatitisBS,
  title={Hepatitis B Surface Antigen as Carrier Matrix for the Repetitive Epitope of the Circumsporozoite Protein of Plasmodium Falciparum.},
  author={Tineke Rutgers and Daniel M. Gordon and A. M. Gathoye and Michael R. Hollingdale and Wayne T. Hockmeyer and Martin Rosenberg and Michel de Wilde},
  journal={Bio/Technology},
  year={1988},
  volume={6},
  pages={1065-1070}
}
The immune dominant repetitive epitope of the circumsporozoite protein of Plasmodium falciparum was fused to the pre-S2 region of the surface antigen of hepatitis B virus within an expression cassette. Yeast cells transformed with vectors carrying the fusions synthesized hybrid proteins that assembled into particles similar to those formed in human serum from the surface antigen alone. These hybrid protein particles expose the circumsporozoite epitope on their exterior and induce a high titer… 

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