Hepatitis B Antigen Loaded Biodegradable Polymeric Nanoparticles: Formulation Optimization and In-vivo Immunization in BALB/c Mice.

@article{Dewangan2018HepatitisBA,
  title={Hepatitis B Antigen Loaded Biodegradable Polymeric Nanoparticles: Formulation Optimization and In-vivo Immunization in BALB/c Mice.},
  author={Hitesh Kumar Dewangan and Sanjay Singh and Lakshmi Maurya and Amrita Srivastava},
  journal={Current drug delivery},
  year={2018},
  volume={15 8},
  pages={
          1204-1215
        }
}
OBJECTIVE The incredibly serious problem of Hepatitis B is virus-related chronic liver disease. The conventional preventive treatment of Hepatitis B requires booster dose, which requires repeated administration of the vaccine to the subject. Thus, there is a need to develop a formulation which can eliminate the need of frequent dosing and enhance patient's acquiescence. To prepare single dose nanovaccine of HBsAg by utilizing central composite design for optimization and interaction of… Expand
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