• Biology, Medicine
• Published in Journal of virology 2014
• DOI:10.1128/JVI.00869-14

Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon.

@article{Wang2014HepatitisAV,
  title={Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon.},
  author={Dang Wang and Liurong Fang and Dahai Wei and Huan Zhang and Rui Luo and Huanchun Chen and Kui Li and Shaobo Xiao},
  journal={Journal of virology},
  year={2014},
  volume={88 17},
  pages={
          10252-8
        }
}

• Dang Wang, Liurong Fang, +5 authors Shaobo Xiao

NEMO (NF-κB essential modulator) is a bridging adaptor indispensable for viral activation of interferon (IFN) antiviral response. Herein, we show that hepatitis A virus (HAV) 3C protease (3Cpro) cleaves NEMO at the Q304 residue, negating its signaling adaptor function and abrogating viral induction of IFN-β synthesis via the retinoic acid-inducible gene I/melanoma differentiation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways. NEMO cleavage and IFN antagonism… CONTINUE READING

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