Hepatic zonation of drug metabolizing enzymes. Studies on hepatocytes isolated from the periportal or perivenous region of the liver acinus.

Abstract

Models of hepatic intraacinar zonation have been proposed previously; in most models, direct visualization of the acinar destruction is not possible while intact hepatocyte recovery-viability often presents a problem for subsequent metabolic studies. In the present studies, the liver is isolated in situ and perfused with Krebs-Henseleit buffer, pH 7.4. A 1… (More)

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@article{GasconBarr1989HepaticZO, title={Hepatic zonation of drug metabolizing enzymes. Studies on hepatocytes isolated from the periportal or perivenous region of the liver acinus.}, author={Marielle Gascon-Barr{\'e} and Noureddine Fikri Benbrahim and Caroline Tremblay}, journal={Canadian journal of physiology and pharmacology}, year={1989}, volume={67 9}, pages={1015-22} }