Hepatic veno‐occlusive disease associated with comfrey ingestion

  title={Hepatic veno‐occlusive disease associated with comfrey ingestion},
  author={Mee Ling Yeong and Boyd Swinburn and Mark Kennedy and G. I. Nicholson},
  journal={Journal of Gastroenterology and Hepatology},
Abstract A 23 year old man presented with hepatic veno‐occlusive disease and severe portal hypertension and subsequently died from liver failure. Light microscopy and hepatic angiography showed occlusion of sublobular veins and small venous radicles of the liver, associated with widespread haemorrhagic necrosis of hepatocytes. The patient had been on a predominantly vegetarian diet and, prior to his illness, took comfrey leaves which are known to contain hepatotoxic pyrrolizidine alkaloids… 
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