Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.

@article{Ma2003HepaticVT,
  title={Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.},
  author={Wenbin Ma and Lino Tessarollo and Seung-Beom Hong and Masaya Baba and Eileen A. Southon and Timothy C. Back and Sally Spence and Corrinne G. Lobe and Nirmala Sharma and Gregory W. Maher and Svetlana Pack and Alexander O. Vortmeyer and Chuanfa Guo and Berton Zbar and Laura S. Schmidt},
  journal={Cancer research},
  year={2003},
  volume={63 17},
  pages={5320-8}
}
von Hippel-Lindau (VHL) disease is a multisystem inherited cancer syndrome characterized by the development of highly vascular tumors including hemangioblastomas of the retina and central nervous system, pheochromocytomas, and clear cell renal carcinoma, which result from somatic inactivation of the wild-type VHL allele in cells harboring a germ-line VHL mutation. Homozygous inactivation of the VHL gene in mice resulted in embryonic lethality. To produce a mouse model that closely mimics human… CONTINUE READING
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5327 VASCULAR LESIONS AND SPERM DEFECTS IN VHL KO MICE on July 20, 2017

  • P. H. Maxwell, M. S. Wiesener, +7 authors P. J. Ratcliffe
  • Nature (Lond.),
  • 2003

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