Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats.

@article{Palombo1993HepaticUO,
  title={Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats.},
  author={John D. Palombo and John L. Bowers and Melvin Eugene Clouse and Arthur McCullough and Robert Armour Forse and Bruce Ryan Bistrian},
  journal={The American journal of clinical nutrition},
  year={1993},
  volume={57 3},
  pages={420-7}
}
The study objective was to assess hepatic utilization of exogenous adenosine or adenine to enhance ATP recovery in rat liver after cold ischemia. ATP was measured noninvasively by 31P nuclear magnetic resonance (NMR) in perfused livers before and after 18 h of cold ischemia. The hepatocellular concentration of ATP during the initial postischemic reperfusion without adenosine or adenine coinfusion was 60% of that in fresh liver. The ATP increased significantly (P < 0.001) to 139% and 82% of… CONTINUE READING