Hepatic triglyceride hydrolysis and development of ketogenesis in rabbits.

@article{Due1985HepaticTH,
  title={Hepatic triglyceride hydrolysis and development of ketogenesis in rabbits.},
  author={Pierre Henri Du{\'e}e and J. P. Pegorier and L el Manoubi and Catherine Herbin and Claude Kohl and Jean Girard},
  journal={The American journal of physiology},
  year={1985},
  volume={249 5 Pt 1},
  pages={E478-84}
}
Ketogenesis from endogenous fatty acids or exogenous oleate plus carnitine has been studied in isolated hepatocytes from fetal, newborn, and 70-day-old rabbits. During the first 48 h after birth, hepatic triacylglycerol stores decrease by 80%. The hydrolysis of hepatic triacylglycerol stores has been studied in isolated hepatocytes from 24-h-old fasting rabbits by using lysosomal acid lipase inhibitors and lysosomotropic agents. Their addition decreases the rates of ketone body production by 60… CONTINUE READING

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