Hepatic transcriptome response to glucocorticoid receptor activation in rainbow trout.

@article{Aluru2007HepaticTR,
  title={Hepatic transcriptome response to glucocorticoid receptor activation in rainbow trout.},
  author={Neelakanteswar Aluru and Mathilakath M Vijayan},
  journal={Physiological genomics},
  year={2007},
  volume={31 3},
  pages={483-91}
}
Cortisol, the principal corticosteroid in teleosts, is thought to play a key role in the metabolic adjustments critical for regaining homeostasis. However, the target tissue molecular mechanisms involved in this adaptive response to corticosteroid stimulation are still unclear. Cortisol signaling is mediated predominantly by the glucocorticoid receptor (GR), and previous studies have shown that RU486 (a GR antagonist) offsets corticosteroid signaling in teleosts. To elucidate the molecular… CONTINUE READING
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