Hepatic subcellular localization of cresylbenzodioxaphosphorin oxide (CBDP)-sensitive soman binding sites.

Abstract

The toxicity of the organophosphorus poison soman (pinacolylmethylphosphonofluoridate) is attributable to its irreversible inhibition of the enzyme acetylcholinesterase. In addition, soman binds irreversibly to a number of noncholinesterase tissue binding sites which appear to be its major means of in vivo detoxification. This study was conducted to… (More)

Topics

Cite this paper

@article{Little1990HepaticSL, title={Hepatic subcellular localization of cresylbenzodioxaphosphorin oxide (CBDP)-sensitive soman binding sites.}, author={Jani S. Little and Donald Maxwell and M K Fox-Talbot and Karen M. Brecht and David E. Lenz}, journal={Biochemical pharmacology}, year={1990}, volume={40 8}, pages={1733-7} }