Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats.

@article{Legraverend1992HepaticSH,
  title={Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats.},
  author={C Legraverend and Agneta Mode and Timothy Wells and Iain C. A. F. Robinson and J A Gustafsson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1992},
  volume={6 2},
  pages={711-8}
}
In rats, the onset of the sexually dimorphic pattern of growth hormone (GH) secretion and increased hepatic GH-binding capacity at puberty are temporally correlated with the sex-dependent expression of some hepatic cytochrome P450 enzymes involved in steroid metabolism. There are indications that the expression of the GH receptor gene itself is dependent on the sexually differentiated pattern of GH secretion. However, the molecular mechanisms by which a given pattern of GH secretion turns on a… CONTINUE READING

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