Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.

@article{Mochizuki2014HepaticSC,
  title={Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice.},
  author={Akie Mochizuki and Aaron Pace and Cheryl E Rockwell and Katherine J. Roth and Aaron K Chow and Kate M. O'Brien and Ryan P Albee and Kara Kelly and Keara L Towery and James P. Luyendyk and Bryan L. Copple},
  journal={Journal of immunology},
  year={2014},
  volume={192 8},
  pages={3847-3857}
}
Hypoxia-inducible factor-1α (HIF-1α) is activated in hepatic stellate cells (HSCs) by hypoxia and regulates genes important for tissue repair. Whether HIF-1α is activated in HSCs after acute injury and contributes to liver regeneration, however, is not known. To investigate this, mice were generated with reduced levels of HIF-1α in HSCs by crossing HIF-1α floxed mice with mice that express Cre recombinase under control of the glial fibrillary acidic protein (GFAP) promoter (i.e., HIF-1α-GFAP… CONTINUE READING

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