Hepatic stellate cells as key target in liver fibrosis.

@article{Higashi2017HepaticSC,
  title={Hepatic stellate cells as key target in liver fibrosis.},
  author={Takaaki Higashi and Scott L Friedman and Yujin Hoshida},
  journal={Advanced drug delivery reviews},
  year={2017},
  volume={121},
  pages={
          27-42
        }
}
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more than one million deaths annually via development of cirrhosis, although no antifibrotic therapy has been approved to date. Transdifferentiation (or "activation") of hepatic stellate cells is the major cellular source of matrix protein-secreting myofibroblasts, the major driver of liver fibrogenesis. Paracrine signals from injured epithelial cells, fibrotic tissue microenvironment, immune and systemic… CONTINUE READING
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