Hepatic stellate cells: partners in crime for liver metastases?

  title={Hepatic stellate cells: partners in crime for liver metastases?},
  author={Ningling Kang and Gregory J. Gores and Vijay H Shah},
  volume={54 2},
UNLABELLED Hepatic stellate cells (HSCs) were recently postulated as a component of the prometastatic liver microenvironment, because they can transdifferentiate into highly proliferative and motile myofibroblasts that are implicated in the desmoplastic reaction and metastatic growth. This review focuses on bidirectional interactions between tumor cells and HSCs in the liver microenvironment and discusses mechanisms whereby tumor-derived factors activate HSCs, and in turn, activated HSCs… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 45 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…