Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives

@article{Zhang2021HepaticSC,
  title={Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives},
  author={Mengfan Zhang and Sandra Alejandra Serna-Salas and Turtushikh Damba and Michaela Borghesan and Marco Demaria and Han Moshage},
  journal={Mechanisms of Ageing and Development},
  year={2021},
  volume={199}
}

Figures and Tables from this paper

The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management

TLDR
The gut microbiota alteration by probiotic co-supplementation in H. pylori management is discussed to predict the comprehensive effectiveness of probiotic oral administration.

Non-alcoholic Fatty Liver Disease and Liver Fibrosis during Aging

TLDR
This review focused on pathways that are key to the aging process in the liver and perpetuate NAFLD/NASH, leading to fibrosis and highlighted recent findings and cross-talks of normal and/or senescent liver cells, dysregulated nutrient sensing, proteostasis and mitochondrial dysfunction in the framework of changing metabolic milieu.

Liver Cytoarchitectonics and Molecular Mechanisms of Regenerative Potential (Literature Review)

Crosstalk between NK cells and hepatic stellate cells in liver fibrosis

TLDR
Clarifying the interaction between NK cells and HSCs will provide clues to the pathogenesis and potential therapies for advanced liver fibrosis.

Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis

TLDR
The present review provides a synopsis of recent antifibrotic treatment modalities for the treatment of liver cirrhosis, as well as a brief summary of clinical trials that have been conducted to date.

References

SHOWING 1-10 OF 233 REFERENCES

Mechanisms of hepatic stellate cell activation

TLDR
These findings reinforce the remarkable complexity and plasticity of HSC activation, and underscore the value of clarifying its regulation in hopes of advancing the development of novel diagnostics and therapies for liver disease.

Senolytic CAR T cells reverse senescence-associated pathologies

TLDR
Chimeric antigen receptor (CAR) T cells targeting uPAR, a cell-surface protein that is upregulated on senescent cells, eliminate senescence cells in vitro and in vivo and reduce liver fibrosis in mice.

Senescent hepatic stellate cells caused by deoxycholic acid modulates malignant behavior of hepatocellular carcinoma

TLDR
The data suggest an important role of HSC senescence caused by DCA for the malignant biological behaviors of HCC via induction of SASP factors, particularly IL8 and TGFβ.

Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype

TLDR
C cultured human HSCs undergo a switch from a fibrogenic to an inflammatory phenotype, suggesting that senescent humanHSCs might modulate chronic wound healing processes and maintenance of telomere length represents an important survival factor for activated human H SCs.

Cellular senescence drives age-dependent hepatic steatosis

TLDR
It is demonstrated that cellular senescence drives hepatic Steatosis and elimination of senescent cells may be a novel therapeutic strategy to reduce steatosis.

Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence

TLDR
A novel insight is provided into the mechanisms underlying curcumin inhibition of HSC activation through inducing senescence through promoting the expression of P53 through a PPARγ activation-dependent mechanism.
...