Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy.

@article{Ramm1995HepaticSC,
  title={Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy.},
  author={Grant A Ramm and Darrell H. G. Crawford and Lawrie W. Powell and Neal I. Walker and Linda M. Fletcher and June W. Halliday},
  journal={Journal of hepatology},
  year={1995},
  volume={26 3},
  pages={
          584-92
        }
}
BACKGROUND/AIMS Activated hepatic stellate cells produce increased levels of collagen in animal models of chronic iron overload; however, their role in human genetic haemochromatosis is unknown. This study examined the relationship between hepatic iron concentration and hepatic stellate cell activation in genetic haemochromatosis. METHODS Liver biopsies from 75 patients (55 with haemochromatosis, 14 haemochromatosis patients both pre- and post-phlebotomy and six non iron-loaded disease… CONTINUE READING

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