Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1.

@article{Wang2005HepaticSI,
  title={Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1.},
  author={A Wang and Sang-Beom Seo and Hyung-Bae Moon and Hye-jun Shin and Dong Hoon Kim and Jin-Man Kim and Tae-Hoon Lee and Ho Jeong Kwon and D Yu and Dong-Seok Lee},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={330 2},
  pages={461-6}
}
It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control… CONTINUE READING

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