Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.

@article{Lin2011HepaticSO,
  title={Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.},
  author={G Y Lin and Jiyao Wang and Na Li and Mi Li and Hong Gao and Yuan Ji and Fan Zhang and Huali Wang and Yan Zhou and Yang Ye and Hong-Xi Xu and Jiang Zheng},
  journal={Journal of hepatology},
  year={2011},
  volume={54 4},
  pages={666-73}
}
BACKGROUND & AIMS One major cause of hepatic sinusoidal obstruction syndrome (HSOS) is the intake of pyrrolizidine alkaloid (PA)-containing products. Over 8000 PA-induced HSOS cases have been reported worldwide and at least 51 among them were suspected to be attributed to exposure to the Chinese medicine 'Tusanqi'. PA-induced hepatotoxicity involves cytochrome P450-mediated metabolic activation of PAs to electrophilic pyrrolic metabolites which react with macromolecules, such as proteins… CONTINUE READING