Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy.

@article{Crawford1997HepaticSO,
  title={Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy.},
  author={Andrew R. Crawford and Anthony James Smith and Victoria Hatch and Ronald P. J. Oude Elferink and Piet Borst and James M. Crawford},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 10},
  pages={2562-7}
}
Hepatocellular secretion of bile salts into the biliary space induces phospholipid and cholesterol secretion, but the mechanism for integrated lipid secretion is poorly understood. Knockout mice unable to make the canalicular membrane mdr2 P-glycoprotein exhibit normal rates of bile salt secretion, yet are virtually incapable of secreting biliary phospholipid and cholesterol. As the mdr2 P-glycoprotein is thought to mediate transmembrane movement of phospholipid molecules, this mouse model was… CONTINUE READING
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Intracellular trafficking and plasma membrane se cretion of small organic solutes involved in hepatocellular bile formation

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The role of vesicle-mediated transport pathways in hepatocellular bile secretion

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