Hepatic secretion of lipoproteins in the rat and the effect of experimental nephrosis.

  title={Hepatic secretion of lipoproteins in the rat and the effect of experimental nephrosis.},
  author={Julian B. Marsh and Charles E. Sparks},
  journal={The Journal of clinical investigation},
  volume={64 5},
Livers from normal and nephrotic rats were perfused by the nonrecirculating technique. Nephrosis was studied on the 7th d after the injection of puromycin animonucleoside. Amino acid-labeled lipoproteins (d < 1.21) were isolated from the perfusion medium by agarose column chromatography or by sequential density ultracentrifugation. In both groups of animals, in addition to very low density lipoproteins and nascent high density lipoproteins, column chromatography revealed the presence of a peak… CONTINUE READING
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