Hepatic reperfusion injury following orthotopic liver transplantation in the rat.

@article{Thurman1988HepaticRI,
  title={Hepatic reperfusion injury following orthotopic liver transplantation in the rat.},
  author={Ronald G. Thurman and I. Marzi and Gordon Seitz and Jochen Thies and John J. Lemasters and Frank Zimmerman},
  journal={Transplantation},
  year={1988},
  volume={46 4},
  pages={502-6}
}
At 24 hr following orthotopic transplantation, rat liver grafts were perfused in situ for 7 min with trypan blue, a vital dye that provides information on hepatic microcirculation and stains nuclei of nonviable cells. Spotty and uneven dye distribution was observed indicating that hepatic microcirculation was disturbed 24 hr following transplantation surgery. Under these conditions, 15-20% of the hepatocytes were nonviable as assessed from trypan blue staining and frank necrosis. In contrast… CONTINUE READING
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