Hepatic progenitor cells of biliary origin with liver repopulation capacity

@inproceedings{Lu2015HepaticPC,
  title={Hepatic progenitor cells of biliary origin with liver repopulation capacity},
  author={Wei-Yu Lu and Thomas G Bird and Luke Boulter and Atsunori Tsuchiya and Alicia McKenna Cole and Trevor Hay and Rachel Victoria Guest and Davina Wojtacha and Tak Yung Man and Alison Mackinnon and Rachel A. Ridgway and Timothy J Kendall and M J Williams and Thomas Jamieson and Alex Raven and David C. Hay and John Peter Iredale and Alan R. Clarke and Owen J Sansom and Stuart J Forbes},
  booktitle={Nature Cell Biology},
  year={2015}
}
Hepatocytes and cholangiocytes self-renew following liver injury. Following severe injury hepatocytes are increasingly senescent, but whether hepatic progenitor cells (HPCs) then contribute to liver regeneration is unclear. Here, we describe a mouse model where the E3 ubiquitin ligase Mdm2 is inducibly deleted in more than 98% of hepatocytes, causing apoptosis, necrosis and senescence with nearly all hepatocytes expressing p21. This results in florid HPC activation, which is necessary for… CONTINUE READING
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