Hepatic production of insulin-like growth factors in normal and diseased liver.

@article{Morali2005HepaticPO,
  title={Hepatic production of insulin-like growth factors in normal and diseased liver.},
  author={Gilles Morali and Ariella Bar-Gil Shitrit and Maya Eran and Serem Freier and Constantin Reinus and David E Braverman},
  journal={Hepato-gastroenterology},
  year={2005},
  volume={52 65},
  pages={
          1511-5
        }
}
BACKGROUND/AIMS IGF-I levels are reduced in cirrhotic patients. However, it is not known whether this decreased level is the result of reduced hepatic production or modified bioavailability secondary to decreased binding proteins. We determined the hepatic production of IGF-I and IGF-II and their receptors in normal and diseased liver. METHODOLOGY Twenty-five patients included, 11 controls with normal liver and 14 with either chronic hepatitis or cirrhosis. mRNA for IGF-1, IGF-II and their… CONTINUE READING